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In vivo DMPK Services

Flexibility in study design and meeting demanding time lines is the strength of the Pharmacelsus in vivo team. We offer DMPK studies in mice, rats, guinea pigs and hamsters. Further preclinically relevant species (e.g. dog, monkey) are available in cooperation with our partners. The Pharmacelsus offering includes complete workflow studies (in-life part, bioanalysis and PK evaluation).


  • Rodents
  • Non-Rodents*

*in cooperation

Application Routes

  • Intravenous (bolus or infusion)
  • Oral (liquid, capsules)
  • Intraperitoneal
  • Subcutaneous (incl. osmotic minipumps)
  • Intramuscular
  • Intradermal
  • Intranasal
  • Topical
  • Intravitreal
  • Intraportal
  • Single, repeated and cassette dosing

Exploratory PK Studies

  • Microsampling / snapshot PK
  • Cassette dosing
  • Major metabolites

Surgical Methods

  • Cannulation (rat)
    • vena jugularis (neck or head attachment)
    • portal vein* (e.g. for evaluation of first-pass effect)
    • bile duct* (e.g. for evaluation of entero-hepatic circulation)
  • Bile duct ligation (rat)
  • Castration

*Animal surgery is conducted
at the provider of rats and mice.

Sampling Methods

  • Jugular catheter
  • Tail vein or artery
  • Sublingual vein
  • Facial vein
  • Plexus retrobulbaris
  • Heart puncture (terminal)
  • Microsampling
  • Tissue perfusion
  • Metabolic cage

Sample Types

  • Whole blood, plasma, dried blood spots
  • Excreta
    • urine
    • faeces
    • bile
  • Bronchioalveolare lavage fluid
  • Cerebrospinal fluid
  • Tissues/organs


  • All markers that can be quantified in biological matrices by validated immuno-assay or LC-MS-methods
  • Sample processing for histology
  • Haematology

Full PK Studies

  • Dose proportionality
  • Organ distribution, excretion, mass balance
  • Metabolite identification
  • First pass effect

All experimental procedures are approved by and conducted in accordance with the regulations of the local Animal Welfare authorities. The Pharmacelsus in vivo department is frequently audited by clients with positive results.

Please contact us for your specific DMPK study!

MUDr. Maria Li
Director Business Development

Anika Christoffel
Team Manager in vivo Pharmacology & Pharmacokinetics